Effect of soy products on graft tumor growth in rats

• Published in: Likars'ka sprava no. 7; pp. 48 - 55
• Main Authors: Zalietok, S P, Orlovs'kyĭ, O A, Hohol', S V, Klenov, O A, Samoĭlenko, O A, Anisimova, Iu M, Borovs'kyĭ, V P, Chekhun, V F
• Format: Journal Article
• Language: Ukrainian
• Published: Ukraine 01.10.2006
• Subjects: Animals; Carcinoma 256, Walker - diet therapy; Carcinoma 256, Walker - metabolism; Female; Male; Neoplasm Transplantation; Neoplasms, Experimental - diet therapy; Neoplasms, Experimental - metabolism; Neoplasms, Hormone-Dependent - diet therapy; Neoplasms, Hormone-Dependent - metabolism; Rats; Soy Foods - adverse effects; Treatment Outcome
• ISSN: 1019-5297

Moderate consumption of a curd-like product made of thermally-treated soy (SPT) led to the retardation of hormone-dependent (Walker W 256 carcinosarcoma in females) and some less hormone-independent (Guerin's carcinoma in males) tumor growth in rats. Excessive (ad libitum) consumption of the same product led to accelaration of W 256 tumor growth. A similar product made of raw soy (SPR) accelerated the growth of W-256 carcinosarcoma and made not any effect on the growth of Guerin's carcinoma. Moderate SPT consumption corrected erythropoesis, decreased lipids peroxidation, retarded peritumoral inflammation, decreased or not changed the content of direct bilirubin in blood serum. SPRconsumption did not lead to those positive effects but sometimes deteriorated those indices. Our experiments have also shown the express-test validity based on dynamical variant of cancerolysis reaction to be practical for evaluation of food quality for cancer patients.