Neuropeptide thyroliberin in ultra low doses--anticonvulsant defense of the brain

Thyroliberin (TRH) promoting endogeneous antidepressive effect is the most general regulator of the central mechanisms and visceral functions (especially respiration). Our group pioneered in applying the anticonvulsant action of TRH after local intranasal application). This application of TRH in ult...

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Published inRadiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 43; no. 3; p. 324
Main Authors Ashmarin, I P, Asanova, L M, Abbasova, K R, Chepurnova, N E, Kossova, G V, Chepurnov, S A, Iniushkin, A N, Goncharov, O B
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.2003
Subjects
Administration, Intranasal
Animals
Anticonvulsants - administration & dosage
Anticonvulsants - metabolism
Anticonvulsants - pharmacology
Brain - drug effects
Brain - physiology
Convulsants - toxicity
Dose-Response Relationship, Drug
Electroencephalography
Male
Pentylenetetrazole - toxicity
Rats
Rats, Wistar
Thyrotropin-Releasing Hormone - administration & dosage
Thyrotropin-Releasing Hormone - metabolism
Thyrotropin-Releasing Hormone - pharmacology
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Summary:Thyroliberin (TRH) promoting endogeneous antidepressive effect is the most general regulator of the central mechanisms and visceral functions (especially respiration). Our group pioneered in applying the anticonvulsant action of TRH after local intranasal application). This application of TRH in ultra-low doses contrast the method of systemic TRH administration in the large doses). In our experiments intranasal application of 10(-8), 10(-10) and 10(-12) mol/l TRH significantly inhibited the severe epileptic motor fits in rats induced by PTZ. EEG also confirms beneficent effect of TRH (TRH suppressed SWD in cortex, amygdala and hippocamp). In the experiment that follows compared effects of TRH (pyroGlu-His-Pro-NH2) and its metabolite dipeptide His-Pro (10(-10), 10(-8) mol/l). The experiments make more precise that only TRH but not His-Pro posses the anticonvulsant properties. There is a good believe that medical potentialities of TRH have not been exhausted and its new possibilities of its usage will be revealed in epileptology.
ISSN:0869-8031