The influence of leu-enkephalin on the bile secretion function in the rat liver during pharmacological modulation of the autonomous nervous system

• Published in: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 55; no. 3; pp. 67 - 74
• Main Authors: Latyshenko, L A, Reshetnik, Ie M, Vesel's'kyĭ, S P, Makarchuk, M Iu
• Format: Journal Article
• Language: Ukrainian
• Published: Ukraine 2009
• Subjects: Adrenergic alpha-Antagonists - pharmacology; Adrenergic beta-Antagonists - pharmacology; Animals; Autonomic Nervous System - drug effects; Autonomic Nervous System - metabolism; Bile - secretion; Enkephalin, Leucine - pharmacology; Liver - innervation; Liver - secretion; Male; Muscarinic Antagonists - pharmacology; Rats
• ISSN: 2522-9028

In acute experiments on rats the influence of ley-enkephalin (1 mkg/100 g) on liver bile secretion function and changes of organic contents of bile were studied. For studying the influence of opioid peptide under conditions of altered state of adreno- and cholinoreceptors, the antagonists of alpha- and beta-adrenoreceptors phentolamin (25 mkg/100 g) and obzidan (5 mkg/100 g), and the blocker of M-holinoreceptors atropine (2 mkg/100 g) were used. The pharmacological modulation of autonomous nervous systems alters the effects of ley-enkephalin on cholesecretions. Opioid peptide in the presence of antagonists of alpha-adrenoreceptors stimulates the processes of bile acids conjugation, in the presence of antagonists of beta-adrenoreceptors it cancels the effects of ley-enkephalin. The antagonists M-holinoreceptors reverse the effects of ley-enkephalin for the opposite ones: the synthesis and transport of free bile asides and cholisterine are suppressed.