Immunity against diphtheria and tetanus in the adult Polish population

The aim of the study was to evaluate immunity against diphtheria and tetanus in healthy adult population in Poland. For determination of antitoxin IgG antibody, toxoid enzyme-linked immunosorbent assay (Toxoid-ELISA) was used. Serum samples were obtained from different regions of Poland and titrated...

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Bibliographic Details
Published inPolski merkuriusz lekarski Vol. 9; no. 52; p. 687
Main Authors Walory, J, Grzesiowski, P, Hryniewicz, W
Format Journal Article
LanguagePolish
Published Poland 01.10.2000
Subjects
Adult
Aged
Diphtheria - immunology
Diphtheria - prevention & control
Diphtheria Toxoid - administration & dosage
Diphtheria Toxoid - immunology
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G - analysis
Middle Aged
Poland - epidemiology
Reference Values
Seroepidemiologic Studies
Tetanus - immunology
Tetanus - prevention & control
Tetanus Toxoid - administration & dosage
Tetanus Toxoid - immunology
Poland
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Summary:The aim of the study was to evaluate immunity against diphtheria and tetanus in healthy adult population in Poland. For determination of antitoxin IgG antibody, toxoid enzyme-linked immunosorbent assay (Toxoid-ELISA) was used. Serum samples were obtained from different regions of Poland and titrated for diphtheria (n = 2442) and tetanus (n = 827) IgG antitoxin. For calibration of anti-toxins determination, the WHO standard of human diphtheria and tetanus antitoxin was used. About 32% (n = 787) of persons were non-protected against diphtheria (IgG-DTAb < 0.1 IU/ml) and 24% (n = 195) against tetanus (IgG-TTAb < 0.1 IU/ml). In 63% (n = 1528) individuals basic protection for diphtheria and 48% (n = 402) for tetanus (0.1-1.0 IU/ml IgG-DTAb and IgG-TTAb) were observed. Only 5% (n = 127) were fully protected for diphtheria and 28% (n = 230) for tetanus (IgG-DTAb and IgG-TTAb > 1.0 IU/ml). In adults between 30-64 years of age, not vaccinated at least during last 10 years, 43% of persons were non-protected. The study showed insufficient immunity against diphtheria in adults. We indicate booster immunisation for selected group of persons.
ISSN:1426-9686