The development, phenotypic characteristics and communications of Schwann cells

The Schwann cell is one of the major cell types in vertebrate peripheral nervous system. The Schwann cell precursors are derived from the neural crest and migrate along the growing axons towards their ultimate localization. Recently obtained data regarding expression of different molecules (S100 pro...

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Bibliographic Details
Published inUspekhi fiziologicheskikh nauk Vol. 31; no. 3; p. 54
Main Authors Chelyshev, Iu A, Saĭtkulov, K I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2000
Subjects
Animals
Apoptosis - physiology
Cell Communication - physiology
Cell Differentiation
Cell Division
Humans
Nerve Regeneration - physiology
Neurons - physiology
Phenotype
Schwann Cells - cytology
Schwann Cells - physiology
Transcription, Genetic - physiology
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Summary:The Schwann cell is one of the major cell types in vertebrate peripheral nervous system. The Schwann cell precursors are derived from the neural crest and migrate along the growing axons towards their ultimate localization. Recently obtained data regarding expression of different molecules (S100 protein, myelin proteins, low-affinity nerve growth factor receptor, GAP-43, adhesion molecules) and particularly transcription factors SCIP and Krox-20 allowed to precisely characterize lineage for myelinating and non myelinating Schwann cells and their phenotypes. The special attention to communication between neurones and Schwann cells is paid. The advance in study of the biology of Schwann cell is of great practical importance for understanding the molecular basis of neuropathies and posttraumatic peripheral nerve regeneration. Schwann cells are also considered as intriguously perspective candidates for transplantation into CNS to stimulate regeneration of axons in brain and spinal cord.
ISSN:0301-1798