Nitric oxide storage in rats of various genetic strains and its role in the antistressor effect of adaptation to hypoxia

Adaptation to hypobaric hypoxia induced a gradual increase in the NO production along with a progressive NO storage in vascular wall. Unadapted August rats were more resistant against stress-induced stomach ulceration than the Wistar rats. Following a 6-day adaptation rats of both strains revealed a...

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Bibliographic Details
Published inRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 86; no. 2; p. 174
Main Authors Pshennikova, M G, Smirin, B V, Bondarenko, O N, Malyshev, I Iu, Manukhina, E B
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.2000
Subjects
Adaptation, Physiological
Animals
Blood Vessels - metabolism
Male
Nitrates - blood
Nitric Oxide - biosynthesis
Nitric Oxide - metabolism
Nitrites - blood
Oxygen - pharmacology
Pressure
Rats
Rats, Wistar
Species Specificity
Stomach Ulcer - etiology
Stomach Ulcer - pathology
Stress, Psychological - blood
Stress, Psychological - complications
Stress, Psychological - metabolism
Time Factors
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Summary:Adaptation to hypobaric hypoxia induced a gradual increase in the NO production along with a progressive NO storage in vascular wall. Unadapted August rats were more resistant against stress-induced stomach ulceration than the Wistar rats. Following a 6-day adaptation rats of both strains revealed a protective antiulcerogenic effect. A long-term adaptation potentiated the stress damage of the stomach rather than protected against it. A higher basal NO production seems to provide a more efficient antistress defence in the August rats. An intense NO storage may create a relative NO shortage and thus predispose to stress-induced vasoconstriction and ulceration.
ISSN:0869-8139