Genetic markers and psoriasis in three ethnic populations of Dagestan

Analysis of clinical material obtained from the individuals (49 psoriasis patients and 357 individuals without this disease) representing three ethnic populations of Dagestan (Avars, Dargins, and Kumyks) was performed. Polymorphism of the blood group loci AB0, Rhesus (RH), Kell, P, and Lewis, as wel...

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Bibliographic Details
Published inGenetika Vol. 41; no. 12; p. 1702
Main Authors Zhukova, O V, Shneĭder, Iu V, Morozova, I Iu, Shil'nokova, I N, Semikov, A V, Goldenkova, I V, Sarkisova, M K, Radzhabov, M O, Markarova, E V, Piruzian, An L
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.2005
Subjects
Blood Group Antigens - genetics
Enzymes - genetics
Ethnic Groups
Female
Genetic Markers - genetics
Homozygote
Humans
Male
Polymorphism, Genetic
Psoriasis - ethnology
Psoriasis - genetics
Russia
Russia
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Summary:Analysis of clinical material obtained from the individuals (49 psoriasis patients and 357 individuals without this disease) representing three ethnic populations of Dagestan (Avars, Dargins, and Kumyks) was performed. Polymorphism of the blood group loci AB0, Rhesus (RH), Kell, P, and Lewis, as well as of the protein-encoding loci for haptoglobin (HP), group-specific component (GC), and the enzymes, including glycosylase (GL01), esterase D (ESD), 6-phosphate dehydrogenase (6PDG), and acid phosphatase (ACP), was studied. It was demonstrated that in the pooled sample of Avars and Kumyks the Lewis system phenotype Le(a-b-) and the RH homozygotes (ee/ee) were statistically significantly more frequent among the psoriasis patients (P = 0.0488 and P = 0.0166, respectively), than among healthy controls of the same ethnic groups. It was suggested that for the pooled sample of Avars and Kumyks, homozygosity for the recessive RH allele (ee/ee) in combination with the Le(a-b-) phenotype, representing homozygosity for recessive allele le, was the risk factor for the development of psoriasis.
ISSN:0016-6758