Liver resistance to CCl(4)-induced injury after stimulation of macrophages with various preparations

Acute toxic hepatitis in male Wistar rats was produced by single injection of 40% CCl(4) (0.2 ml per 100 g body weight in oil). Pretreatment with various immunostimulators (bacterial polysaccharides prodigiozan and salmozan; yeast polysaccharides zymosan, peptidoglycan, and mannan; and hydrolytic en...

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Published inBulletin of experimental biology and medicine Vol. 129; no. 6; p. 524
Main Authors Kutina, S N, Zubakhin, A A
Format Journal Article
LanguageEnglish
Published United States 01.06.2000
Subjects
Adjuvants, Immunologic - pharmacology
Alanine Transaminase - blood
Animals
Carbon Tetrachloride - toxicity
Chemical and Drug Induced Liver Injury - metabolism
Chemical and Drug Induced Liver Injury - pathology
Chemical and Drug Induced Liver Injury - prevention & control
Liver - drug effects
Liver - metabolism
Liver - pathology
Macrophages - drug effects
Macrophages - metabolism
Mannans - pharmacology
Muramidase - pharmacology
Peptidoglycan - pharmacology
Polysaccharides, Bacterial - pharmacology
Prodigiozan - pharmacology
Prostaglandins E - analysis
Rats
Rats, Wistar
Zymosan - pharmacology
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Summary:Acute toxic hepatitis in male Wistar rats was produced by single injection of 40% CCl(4) (0.2 ml per 100 g body weight in oil). Pretreatment with various immunostimulators (bacterial polysaccharides prodigiozan and salmozan; yeast polysaccharides zymosan, peptidoglycan, and mannan; and hydrolytic enzyme egg lysozyme) produced a hepatoprotective effect correlating which the stimulatory influence on macrophages and increasing in the following order: mannan<peptidoglycan<zymosan<lysozyme<salmozan<prodigiozan.
ISSN:0007-4888