Chronic hepatitis C in HIV co-infected patients. Study of 55 cases with liver biopsy

To study the evolution of chronic hepatitis in HIV-HCV co-infected patients and the factors conditioning this evolution. 55 intravenous drug users with HIV-HCV co-infection were studied. We performed a clinical and laboratory study determining the age at the time of HCV infection and the date of liv...

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Bibliographic Details
Published inMedicina clínica Vol. 123; no. 12; p. 441
Main Authors Rubio Caballero, Manuel, Rubio Rivas, Carmen, Egido García, Ramón, Nogués Biau, Antonio
Format Journal Article
LanguageSpanish
Published Spain 09.10.2004
Subjects
Adult
Biopsy
Female
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - pathology
HIV Infections - complications
HIV Infections - immunology
Humans
Male
Substance Abuse, Intravenous - complications
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Summary:To study the evolution of chronic hepatitis in HIV-HCV co-infected patients and the factors conditioning this evolution. 55 intravenous drug users with HIV-HCV co-infection were studied. We performed a clinical and laboratory study determining the age at the time of HCV infection and the date of liver biopsy, HIV stage, CD4 cell count, viral load, and time under antiretroviral treatment. Moreover, we analyzed the HCV genotype, HCV viral load, ALT plasmatic level, and liver biopsy. Univariate and multivariate analyses were made. 55 patients with HIV-HCV co-infection were evaluated. In the multivariate analysis, gender (p = 0.034; 95% confidence interval [CI], 1.306-1082.625), lowest level of CD4+ lymphocytes (p = 0.021; 95% CI, 1,693-653,484) and highest viral load value (p = 0.022; 95% CI, 1366-53,817) were significantly correlated with liver disease progression. Both a male sex and a poor immune system situation are associated with a worse evolution of chronic hepatitis C.
ISSN:0025-7753