Detection of tissue specific antigen-binding lymphocytes in patients with acute enteric infections

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 5; p. 71
• Main Authors: Slavko, E A, Karal'nik, B V, Karabekov, A Zh, Deriabin, P N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.2002
• Subjects: Acute Disease; Antigens - analysis; Duodenum - immunology; Dysentery, Bacillary - blood; Dysentery, Bacillary - immunology; Enterobacteriaceae Infections - blood; Enterobacteriaceae Infections - immunology; Enterocolitis - blood; Enterocolitis - immunology; Erythrocytes; Gastroenteritis - blood; Gastroenteritis - immunology; Humans; Intestinal Mucosa - immunology; Intestine, Large - immunology; Intestine, Small - immunology; Lymphocytes - immunology; Organ Specificity; Salmonella Infections - blood; Salmonella Infections - immunology
• ISSN: 0372-9311

A total of 88 patients with salmonellosis, acute dysentery, alimentary toxicoinfection, acute gastroenterocolitis were examined. The study was aimed at early determination of the involvement of organs and tissues into the inflammatory process and detection of antigen-binding lymphocytes with the use of erythrocytic immunoreagents prepared from tissue antigens of mucous membranes of small and large intestine, duodenum, stomach, gall bladder, as well as liver and pancreas. The study demonstrated that as early as on day 1-3 of the disease the development of the inflammatory process in different organs was accompanied by the appearance of the corresponding tissue specific (organ specific) antigen-binding lymphocytes in all patients. As a rule, patients with different acute enteric diseases significantly differed by the frequency and spectrum of the involvement of such organs and tissues into pathological process.