Neuroimmunoendocrine interaction in the pathogenesis of chronic heart failure

Chronic heart failure (CHF) is a common complication of patients with heart dysfunction and of those suffering from various chronic illnesses. Although recently developed therapies revolutionized treatment of CHF, life expectancy of the survivors is still significantly reduced. Proposed neurohoromon...

Full description

Saved in:
Bibliographic Details
Published inUspekhi fiziologicheskikh nauk Vol. 34; no. 3; p. 3
Main Authors Poskrebysheva, A S, Grinevich, V V, Smurova, Iu V, Shostak, N A, Akmaev, I G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2003
Subjects
Animals
Atrial Natriuretic Factor - physiology
Chemokines - physiology
Chronic Disease
Cytokines - physiology
Heart Failure - etiology
Heart Failure - immunology
Heart Failure - therapy
Humans
Interleukin-1 - physiology
Interleukin-10 - physiology
Interleukin-6 - physiology
Neuroimmunomodulation
Neurosecretory Systems - physiopathology
Renin-Angiotensin System - physiology
Sympathetic Nervous System - physiopathology
Tumor Necrosis Factor-alpha - physiology
Online AccessGet more information

Cover

More Information
Summary:Chronic heart failure (CHF) is a common complication of patients with heart dysfunction and of those suffering from various chronic illnesses. Although recently developed therapies revolutionized treatment of CHF, life expectancy of the survivors is still significantly reduced. Proposed neurohoromonal approach in CHF treatment is on the whole rather unsatisfactory. Recently the interest of clinical investigators has been focused on immune mechanisms in the pathogenesis of CHF. In this review we tried to summarize data concerning contribution of inflammatory cytokines to pathogenesis of CHF. The source and site of action of pro- and antiinflammatory cytokines and number of interactions among cytokines and neuroendocrine systems under CHF are considered. Finally we discuss novel therapies managing correction of both immune and neurohormonal status of the patient.
ISSN:0301-1798