Tumor markers in epithelial ovarian cancer

Many circulating markers are already in clinical practice and in experimental use for the diagnosis, therapeutic monitoring, and in the follow-up of ovarian cancer. The cancer antigen-125 (CA-125) has shown to be useful in epithelial ovarian cancer, but its specificity is too low for the test to be...

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Bibliographic Details
Published inMinerva ginecologica Vol. 55; no. 4; p. 327
Main Authors Di Cocco, B, Calabretta, F, Alghisi, F, Salesi, N, Bossone, G
Format Journal Article
LanguageItalian
Published Italy 01.08.2003
Subjects
Antigens, Neoplasm - blood
Biomarkers, Tumor - blood
CA-125 Antigen - blood
Carcinoembryonic Antigen - blood
Carcinoma - blood
Carcinoma - diagnosis
Female
Glycoproteins - blood
Humans
Ovarian Neoplasms - blood
Ovarian Neoplasms - diagnosis
Tissue Polypeptide Antigen - blood
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Summary:Many circulating markers are already in clinical practice and in experimental use for the diagnosis, therapeutic monitoring, and in the follow-up of ovarian cancer. The cancer antigen-125 (CA-125) has shown to be useful in epithelial ovarian cancer, but its specificity is too low for the test to be used as a primary screening technique in early stage and particularly in premenopausal women. In the last few years, several studies have focused on using the serial measurement of complementary serum markers to improve the positive predictive value and diagnostic accuracy. The main problem is that the different cellular lines express these markers in a very variable way.
ISSN:0026-4784