Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate

The effects of GABA - docosahexaenoyldopamine (DHED) conjugate on the cerebral haemodynamics and thrombocyte aggregation were evaluated and compared to these of docosahexaenoyldopamine alone. The GABA - DHED conjugate was shown to significantly enhance the cerebral circulation in rats with a model o...

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Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 71; no. 4; p. 26
Main Authors Kurdiumov, I N, Gan'shina, T S, Mirzoian, N R, Vasil'eva, T M, Makarov, V A, Petrukhina, G N, Bezuglov, V V, Gretskaia, N M, Zinchenko, G N, Mirzoian, R S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2008
Subjects
Animals
Cerebrovascular Circulation - drug effects
Dopamine - analogs & derivatives
Dopamine - pharmacology
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - pharmacology
Humans
Male
Platelet Activating Factor - drug effects
Rats
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Summary:The effects of GABA - docosahexaenoyldopamine (DHED) conjugate on the cerebral haemodynamics and thrombocyte aggregation were evaluated and compared to these of docosahexaenoyldopamine alone. The GABA - DHED conjugate was shown to significantly enhance the cerebral circulation in rats with a model of global transient cerebral ischemia, as compared to the intact animals. Administered alone, DHED increased the blood supply of both intact and ischemic brains to an equal extent. The GABA-DHED conjugate demonstrated the antiaggregative activity, but the effect was less expressed than that of DHED alone.
ISSN:0869-2092