Effects of recombinant IL-4delta2 on human peripheral blood mononuclears

In human cells, expression of IL-4 gene involves alternative mRNA splicing. IL-4delta2 splice variant is an antagonist of full-length IL-4 protein and blocks its effect on the functional activity of immunocompetent cells. The effect of recombinant IL-4delta2 on cytokine-producing activity of human p...

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Published inBulletin of experimental biology and medicine Vol. 143; no. 1; pp. 72 - 74
Main Authors Silkov, A N, Gavrilenko, V A, Denisova, V V, Grishina, L V, Kozlov, V A, Sennikov, S V
Format Journal Article
LanguageEnglish
Published United States 01.01.2007
Subjects
Alternative Splicing
Cell Proliferation - drug effects
Humans
Immunoglobulin E - biosynthesis
Immunoglobulin E - blood
In Vitro Techniques
Interleukin-4 - genetics
Interleukin-4 - pharmacology
Interleukin-6 - biosynthesis
Interleukin-6 - blood
Interleukin-6 - genetics
Leukocytes, Mononuclear - cytology
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Recombinant Proteins - pharmacology
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Summary:In human cells, expression of IL-4 gene involves alternative mRNA splicing. IL-4delta2 splice variant is an antagonist of full-length IL-4 protein and blocks its effect on the functional activity of immunocompetent cells. The effect of recombinant IL-4delta2 on cytokine-producing activity of human peripheral blood mononuclear cells is shown for the first time.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888