Genetic susceptibility to cancer

Hereditary predisposition is a common trait of many cancers. 15 to 20 percent of all cancers occur in individuals who have inherited a single gene alteration being members of families where multiple persons carry a high risk of developing cancer. Other than these so-called high penetrance genes whic...

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Bibliographic Details
Published inRevista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi Vol. 104; no. 2; p. 21
Main Authors Stoica, O, Sandovici, I, Covic, M
Format Journal Article
LanguageRomanian
Published Romania 01.04.2000
Subjects
Gene Expression Regulation, Neoplastic - genetics
Genes, Tumor Suppressor
Genetic Predisposition to Disease - genetics
Humans
Mutation - genetics
Neoplasms - genetics
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Summary:Hereditary predisposition is a common trait of many cancers. 15 to 20 percent of all cancers occur in individuals who have inherited a single gene alteration being members of families where multiple persons carry a high risk of developing cancer. Other than these so-called high penetrance genes which confer elevated risks of cancer development, there are many other genes that generate less dramatic but clinically important risks of cancer, often only if associated to specific exposures.
ISSN:0048-7848