Extrinsic allergic alveolitis. Clinical experience at the Instituto National de Enfermedades Respiratorias (INER)

Extrinsic allergic alveolitis is an interstitial lung disease caused by exposure to a variety of inhaled antigens. In Mexico, the most frequent form is due to the inhalation of avian antigens, markedly pigeon proteins. Depending on type and time exposure, the disease presents different clinical form...

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Bibliographic Details
Published inGaceta médica de México Vol. 135; no. 6; p. 577
Main Authors Chapela-Mendoza, R, Selman-Lama, M
Format Journal Article
LanguageSpanish
Published Mexico 01.11.1999
Subjects
Administration, Oral
Adrenal Cortex Hormones - administration & dosage
Adrenergic beta-Agonists - administration & dosage
Alveolitis, Extrinsic Allergic - diagnosis
Alveolitis, Extrinsic Allergic - drug therapy
Alveolitis, Extrinsic Allergic - pathology
Anti-Inflammatory Agents - administration & dosage
Beclomethasone - administration & dosage
Biopsy
Bird Fancier's Lung - complications
Bird Fancier's Lung - diagnosis
Bird Fancier's Lung - drug therapy
Bird Fancier's Lung - pathology
Bronchoalveolar Lavage Fluid
Clinical Trials as Topic
Colchicine - administration & dosage
Female
Follow-Up Studies
Humans
Lung - pathology
Male
Prognosis
Prospective Studies
Pulmonary Fibrosis - etiology
Pulmonary Fibrosis - pathology
Radiography, Thoracic
Respiratory Function Tests
Respiratory Therapy
Time Factors
Tomography, X-Ray Computed
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Summary:Extrinsic allergic alveolitis is an interstitial lung disease caused by exposure to a variety of inhaled antigens. In Mexico, the most frequent form is due to the inhalation of avian antigens, markedly pigeon proteins. Depending on type and time exposure, the disease presents different clinical forms usually characterized by progressive dyspnea, ground glass or reticulonodular images on chest x rays, a restrictive functional pattern, rest hypoxemia worsening with exercise, and increase of T lymphocytes in bronchoalveolar lavage with an inversion in the helper/suppressor ratio. In this paper, we discuss a 15-year experience with this pathological problem in Mexico, emphasizing the differences with this disorder in Caucasian populations. Generally, our patients display a chronic form of the disease, which evolves to fibrosis in about one-half of the patients. In this sense, the diagnostic, prognostic, and therapeutic focusing exhibit different elements, and thus the development of clinical and basic research is strongly required.
ISSN:0016-3813