Experimental validation of licopin-containing drug tomatol use in combined therapy of patients with diabetic retinopathy

Effects of tomatol on metabolic changes in the blood and lacrimal fluid and ocular capillaries of rabbits with alloxane diabetes were studied. Tomatol is a drug containing licopin carotenoid characterized by a high biological activity. The intensity of lipid peroxidation was notably decreased, antio...

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Published inVestnik oftal'mologii Vol. 116; no. 5; p. 31
Main Authors Chesnokova, N B, Grigor'ev, A V, Kuznetsova, T P, Davydova, N G, Olfer'ev, A M, Kost, O A, Nikol'skaia, I I, Kapitanov, A B
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2000
Subjects
Alloxan - toxicity
Animals
Antioxidants - therapeutic use
Carotenoids - therapeutic use
Diabetic Retinopathy - chemically induced
Diabetic Retinopathy - drug therapy
Diabetic Retinopathy - metabolism
Diabetic Retinopathy - pathology
Endopeptidases - metabolism
Lipid Peroxidation - drug effects
Rabbits
Retinal Vessels - pathology
Tears - metabolism
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Summary:Effects of tomatol on metabolic changes in the blood and lacrimal fluid and ocular capillaries of rabbits with alloxane diabetes were studied. Tomatol is a drug containing licopin carotenoid characterized by a high biological activity. The intensity of lipid peroxidation was notably decreased, antioxidant activity of the blood increased, lipid metabolism parameters in the blood and some parameters of proteinase inhibitory balance in the blood and lacrimal fluid normalized in diabetic rabbits treated with tomatol in comparison with untreated rabbits. Changes in perilimbic capillaries were less expressed in treated vs. untreated animals. Hence, tomatol is recommended for combined therapy of patients with diabetes as a drug normalizing metabolism and probably decelerating the development of diabetic retinopathy.
ISSN:0042-465X