Alternative pathways for the activation of the renin-angiotensin system

The knowledge of the structure and function of the components of the renin-angiotensin system (RAS) is rapidly increasing. The classic pathway of angiotensin (Ang) II generation includes a reaction catalyzed by angiotensin-converting enzyme (ACE). We actually discuss the alternative pathways for the...

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Bibliographic Details
Published inRevista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi Vol. 107; no. 4; p. 710
Main Authors Gurzu, B, Costuleanu, M, Petrescu, Gh
Format Journal Article
LanguageRomanian
Published Romania 01.10.2003
Subjects
Angiotensin II - physiology
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Cathepsins - metabolism
Chymases
Glutamyl Aminopeptidase - metabolism
Humans
Neprilysin - metabolism
Renin-Angiotensin System - drug effects
Renin-Angiotensin System - physiology
Serine Endopeptidases - metabolism
Tissue Kallikreins - metabolism
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Summary:The knowledge of the structure and function of the components of the renin-angiotensin system (RAS) is rapidly increasing. The classic pathway of angiotensin (Ang) II generation includes a reaction catalyzed by angiotensin-converting enzyme (ACE). We actually discuss the alternative pathways for the generation of Ang-II and other angiotensin peptides (Ang III, Ang IV, Ang (1-9), Ang (1-7), des-Asp-Ang I) and the responsible enzymes (tonins, cathepsins, chymases, aminopeptidases, dipeptidyl aminopeptidases, neutral endopeptidases, carboxypeptidases, ACE2 etc.). The development of novel enzyme inhibitors (e.g., nafamostat, sampatrilat) for more efficacious suppression of RAS activity is also considered.
ISSN:0048-7848