Glycol ethers reproductive risks

• Published in: Gynécologie, obstétrique & fertilité Vol. 34; no. 10; p. 955
• Main Author: Cicolella, A
• Format: Journal Article
• Language: French
• Published: France 01.10.2006
• Subjects: Abnormalities, Drug-Induced; Abortion, Spontaneous - chemically induced; Environmental Exposure - legislation & jurisprudence; Ethylene Glycols - toxicity; Female; France; Humans; Infertility - chemically induced; Male; Pregnancy; Reproduction; Solvents; France
• ISSN: 1297-9589

Glycol ethers (GE) are a family of solvents, the use of which has increased dramatically since the 60's, in domestic and occupational mainly water-based products, such as paintings, inks, varnishes, cleaning agents. There are two subgroups: E series and P series. EGME, among the E series, is the reference substance. This is a reprotoxic chemical causing infertility and genital apparatus atrophy on both sexes, embryofetal toxicity through maternal exposure (malformation, growth alterations and functional deficits). European Union has classified nine other GE as reprotoxic. P series, with the beta isomers exception, has no specific reprotoxicity. Epidemiological studies published from the 80's onwards, have confirmed animal data (malformation, oligoazoospermia, spontaneous abortion, hypofertility). The effects can be observed even after the end of exposure. Risk assessment studies tend to prove that this massive exposure during several decades could have had an important impact on reproductive human health. Even if this exposure has considerably decreased since the last few years, a ban of reprotoxic GE, as required by two official bodies (CSC, CSHPF), seems necessary, due to the high risk level. Classification should be completed for some GE, not classified now (EGBE). Health assessment of past exposure should be carried out. Physicians should look after a possible glycol ethers responsibility when facing this kind of reprotoxic effects.