Papilloma virus infection in pretumor and tumor masses of the larynx

• Published in: Vestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 12; p. 36
• Main Authors: Balukova, O V, Shcherbak, L N, Savelov, N A, Ungiadze, G V, Zborovskaia, I B
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2004
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - virology; Diagnosis, Differential; DNA, Viral - analysis; Female; Fibroma - diagnosis; Fibroma - etiology; Fibroma - virology; Humans; Immunohistochemistry; Keratosis - diagnosis; Keratosis - etiology; Keratosis - virology; Laryngeal Mucosa - virology; Laryngeal Neoplasms - diagnosis; Laryngeal Neoplasms - etiology; Laryngeal Neoplasms - virology; Male; Middle Aged; Papilloma - diagnosis; Papilloma - etiology; Papilloma - virology; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - complications; Parakeratosis; Polymerase Chain Reaction; Precancerous Conditions - diagnosis; Precancerous Conditions - etiology; Sex Factors; Smoking - adverse effects; Virology
• ISSN: 0869-6047

There has been recent evidence suggesting that papilloma virus infection is of no small importance in the pathogenesis of tumors of the head and neck. This study has involved a screening of the mucosa having laryngeal pretumors and tumors for papilloma virus infection by polymerase chain reaction and immunohistochemistry. Specimens were studied in 130 patients. All the patients with laryngeal papillomatosis were found to have human papilloma virus (HPV) types 6 and 11. HPV-18 was detected in 6 (13%) of 48 cases of laryngeal cancer and in 4 (9%) of 46 cases of laryngeal mucosal precancer. Mixed HPV infection of 2-3 different types was revealed in 6 (20%) of 30 HPV-positive patients. Such a wide survey of laryngeal pretumors and tumors in the Russian population for virus infection has been conducted for the first time.