Antitumor effect of natural avermectins

The effects of the natural avermectin complex, aversectin C and individual avermectin B1 on the growth of ascitic and solid transplantable tumors in animals were studied. The results showed for the first time that both aversectin C and avermectin B1 possessed marked antitumor activity. In subtoxic d...

Full description

Saved in:
Bibliographic Details
Published inAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 49; no. 5; p. 8
Main Authors Driniaev, V A, Mosin, V A, Krugliak, E B, Sterlina, T S, Novik, T S, Ermakova, N V, Kublik, L N, Levitman, M Kh, Shaposhnikova, V V, Korystov, Iu N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2004
Subjects
Administration, Oral
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
Carcinoma, Ehrlich Tumor - drug therapy
Carcinoma, Ehrlich Tumor - pathology
Cell Proliferation - drug effects
Drug Screening Assays, Antitumor
Injections, Intraperitoneal
Injections, Subcutaneous
Ivermectin - administration & dosage
Ivermectin - analogs & derivatives
Ivermectin - pharmacology
Leukemia P388 - drug therapy
Leukemia P388 - pathology
Male
Mice
Online AccessGet more information

Cover

More Information
Summary:The effects of the natural avermectin complex, aversectin C and individual avermectin B1 on the growth of ascitic and solid transplantable tumors in animals were studied. The results showed for the first time that both aversectin C and avermectin B1 possessed marked antitumor activity. In subtoxic doses aversectin C significantly inhibited the growth of P388 lymphoid leukemia and Ehrlich carcinoma, both ascitic and solid ones. In some administration regimens aversectin C inhibited the tumor growth by 70 to 80%. The highest effect of aversectin C was observed after its intraperitoneal administration. Avermectin B1 inhibited the growth of solid Ehrlich carcinoma and carcinoma 755.
ISSN:0235-2990