Study of the possibility of hyperparathyroidism development in rats exposed to internal irradiation by iodine radioisotope

The possibility of hyperparathyroidism development secondary to earlier internal irradiation with radioactive iodine was studied experimentally in Wistar rats. This report describes the parathyroid morphology and biochemical findings for animals irradiated with 131I at the doses of 4.5, 40, or 80 Gy...

Full description

Saved in:
Bibliographic Details
Published inRadiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 42; no. 1; p. 80
Main Authors Budagov, R S, Chureeva, L N, Chibisova, O F, Barbarykina, G S, Petrov, V N, Podgorodnichenko, V K, Belorukova, N V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2002
Subjects
Animals
Calcium - blood
Female
Fibrosis - pathology
Hyperparathyroidism - blood
Hyperparathyroidism - etiology
Hyperparathyroidism - pathology
Iodine Radioisotopes - administration & dosage
Iodine Radioisotopes - adverse effects
Male
Parathyroid Glands - pathology
Parathyroid Glands - radiation effects
Radiation Dosage
Rats
Rats, Wistar
Thyroid Gland - pathology
Thyroid Gland - radiation effects
Time Factors
Online AccessGet more information

Cover

More Information
Summary:The possibility of hyperparathyroidism development secondary to earlier internal irradiation with radioactive iodine was studied experimentally in Wistar rats. This report describes the parathyroid morphology and biochemical findings for animals irradiated with 131I at the doses of 4.5, 40, or 80 Gy. The interval between the radiation exposure of two-month-old rats and their examination for thyroid and parathyroid pathology was 14 months. Neither hypercalcemia nor hypophosphatemia was found. Moreover, the level of calcium in serum slightly decreased following 40 and 80 Gy irradiation. The increased incidence of parathyroid fibrosis and hypofunctional structure transformation were revealed.
ISSN:0869-8031