Relationship between lymphatic metastasis in breast and cervix cancers and the level of CD44-H expression evaluated by an immunohistochemical method

• Published in: Gynécologie, obstétrique & fertilité Vol. 29; no. 6; pp. 422 - 426
• Main Authors: Yahyaoui, O, Guerbaoui, M, Oudghiri, M
• Format: Journal Article
• Language: French
• Published: France 01.06.2001
• Subjects: Antibodies, Monoclonal; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - immunology; Carcinoma, Ductal, Breast - pathology; Carcinoma, Squamous Cell - immunology; Carcinoma, Squamous Cell - pathology; Coloring Agents; Female; Humans; Hyaluronan Receptors - analysis; Immunohistochemistry; Lymphatic Metastasis; Periodic Acid-Schiff Reaction; Uterine Cervical Neoplasms - immunology; Uterine Cervical Neoplasms - pathology
• ISSN: 1297-9589

Immunohistochemistry has been used to evaluate the relationship between the rate of CD44-H antigen expression in breast invasive intracanalicuar and cervical epidermoïd carcinomas and the presence of node metastasis. A total of 36 cases of breast carcinoma and 20 cases of cervical carcinoma was examined. For the two types of carcinoma, the CD44-H molecule was highly expressed in cases with node metastasis; with 50% and 75% median value of CD44-H positive tumor cells respectively for the breast (p < 0.02) and for the uterine cervix (p < 0.05) compared to respectively 10% and 37.5% in the cases without node metastasis. The expression of this molecule increases with invasive potential of tumor cells and the use of this antigen for prognostic ends may be possible.