A model of the dynamics of intracellular calcium based on refined kinetics of inhibiting the inositol-1,4,5-trisphoshate-sensitive calcium channel

Several new models of intracellular calcium dynamics based on refined inositol-1,4,5-triphosphate-sensitive calcium channel kinetics were studied. The refined kinetic schemes take into account that a cytosolic calcium cannot inhibit inositol-1,4,5-triphosphate receptors when they are bound to inosit...

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Bibliographic Details
Published inBiofizika Vol. 47; no. 1; p. 31
Main Authors Veresov, V G, Kabak, A G, Volotovskiĭ, I D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2002
Subjects
Calcium - metabolism
Calcium Channels - metabolism
Inositol 1,4,5-Trisphosphate - metabolism
Kinetics
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Summary:Several new models of intracellular calcium dynamics based on refined inositol-1,4,5-triphosphate-sensitive calcium channel kinetics were studied. The refined kinetic schemes take into account that a cytosolic calcium cannot inhibit inositol-1,4,5-triphosphate receptors when they are bound to inositol-1,4,5-triphosphate. The mathematical analysis of intracellular calcium dynamics based on one of these schemes allowed us to show how different types of Ca response to extracellular stimuli, such as excitability, oscillations, sustained elevation of Ca and frequency encoding can arise with a reasonably good fit to experimental data.
ISSN:0006-3029