Use of cytochrome C in the prevention of myocardial reperfusion injury during heart valve prosthesis implantation under conditions of extracorporeal circulation

Cytochrome C used at the postischemic period causes a rapid reestablishment of coronary circulation, hemodynamic parameters, prevents activation of lipid peroxidation in reoxygenation of the heart after prolonged total myocardial ischemia in patients with acute bacterial endocarditis in whom the pro...

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Bibliographic Details
Published inVestnik hirurgii im. I.I. Grekova Vol. 160; no. 1; p. 15
Main Authors Boiarinov, G A, Iakovlev, A Iu, Teziaeva, S A, Mukhina, I V, Boiarinova, L V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2001
Subjects
Animals
Coronary Circulation
Cytochrome c Group - therapeutic use
Endocarditis, Bacterial - surgery
Extracorporeal Circulation
Heart Valve Prosthesis Implantation - mortality
Hemodynamics
Hospital Mortality
Humans
Lipid Peroxidation
Myocardial Reperfusion Injury - prevention & control
Rats
Time Factors
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Summary:Cytochrome C used at the postischemic period causes a rapid reestablishment of coronary circulation, hemodynamic parameters, prevents activation of lipid peroxidation in reoxygenation of the heart after prolonged total myocardial ischemia in patients with acute bacterial endocarditis in whom the prostheses of heart valves had been fulfilled. Parallel with the positive inotropic effect, Cytochrome C reduces the postloading and, as a result, transfers the cardiac muscle to a more profitable regimen. At the end of the myocardial ischemia period Cytochrome C provides rapid and effective recovery of the bioelectrical function of the heart, improves its pumping function, thus allowing the dose and duration of inotropic stimulation of the myocardium at the postischemic period to be reduced, lowers pulmonary resistance and finally leads to less postoperative intrahospital lethality from acute heart failure.
ISSN:0042-4625