Implication of ermX genes in macrolide- and telithromycin-resistance in Corynebacterium jeikeium and Corynebacterium amycolatum

The activity of seven macrolides, clindamycin and telithromycin against clinical isolates of Corynebacterium spp. was studied. Of these, 36 isolates were identified as C. jeikeium and 57 as C. amycolatum. The frequency of resistance to erythromycin and other macrolides as well as clindamycin was hig...

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Published inRevista española de quimioterapia Vol. 18; no. 3; pp. 236 - 242
Main Authors Yagüe Guirao, G, Mora Peris, B, Martínez-Toldos, M C, Rodríguez González, T, Valero Guillén, P L, Segovia Hernández, M
Format Journal Article
LanguageSpanish
Published Spain 01.09.2005
Subjects
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - genetics
Corynebacterium - drug effects
Corynebacterium - genetics
Drug Resistance, Bacterial - genetics
Humans
Ketolides - pharmacology
Macrolides - pharmacology
Microbial Sensitivity Tests
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Summary:The activity of seven macrolides, clindamycin and telithromycin against clinical isolates of Corynebacterium spp. was studied. Of these, 36 isolates were identified as C. jeikeium and 57 as C. amycolatum. The frequency of resistance to erythromycin and other macrolides as well as clindamycin was high, with CMI(90) >256 microg/ml. Telithromycin showed the best activity, with 52.3% of C. amycolatum and 70% of C. jeikeium erythromycin-resistant strains susceptible to this ketolide. All strains had the MLSb constitutive phenotype. The ermX gene was present in all erythromycin-resistant strains, and in C. amycolatum was 100% homologous with that of C. striatum and C. diphtheriae.
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ISSN:0214-3429