Notch signaling in chondrogenesis

Notch is a signaling molecule which plays a critical role in the determination of multiple cellular differentiation pathways and morphogenesis in various biological systems, such as neurogenesis, immune system, and hematopoiesis. However, roles of Notch signaling in osteo/chondrogenesis have not bee...

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Bibliographic Details
Published inClinical calcium Vol. 16; no. 8; p. 1374
Main Authors Fujimaki, Ryoji, Tezuka, Ken-ichi
Format Journal Article
LanguageJapanese
Published Japan 01.08.2006
Subjects
Animals
Cells, Cultured
Chondrogenesis - physiology
Mice
Receptors, Notch - physiology
Signal Transduction
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Summary:Notch is a signaling molecule which plays a critical role in the determination of multiple cellular differentiation pathways and morphogenesis in various biological systems, such as neurogenesis, immune system, and hematopoiesis. However, roles of Notch signaling in osteo/chondrogenesis have not been well studied. We will present our recent progress in investigating roles of Notch signaling in chondrogenesis using in vitro chondrogenic system. We will also discuss about the recent reports which used conditional knockout mice to investigate roles of Notch signaling molecules in vivo .
ISSN:0917-5857