Specific long-term cellular changes under effects of low doses of radiation
We examined the peculiar form of a tissue postirradiative reaction characterizing by massive, dose-independent transition of cell populations to the steady state modification with the essential raise of cell damage and cell loss probability as compared with the probability level of the same alterati...
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Published in | Radiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 42; no. 1; p. 20 |
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Main Authors | , , |
Format | Journal Article |
Language | Russian |
Published |
Russia (Federation)
01.01.2002
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Subjects | |
Online Access | Get more information |
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Summary: | We examined the peculiar form of a tissue postirradiative reaction characterizing by massive, dose-independent transition of cell populations to the steady state modification with the essential raise of cell damage and cell loss probability as compared with the probability level of the same alterations in controls. We described some other signs of such type of cellular transformation. It was found that the indicated cellular condition occurred both in active and slowly proliferating tissues. The reaction occurred at relatively low doses of irradiation. Some nonmutagenic factors also may evoke such effects. Our experimental data allow us to suppose the epigenetic mechanizms taking part in the induction and preservation of such alterations. The discovered form of cellular reaction manifestating in different biological objects may be considered as some general biological tendency. The importance of the studied reaction in the pathogenesis of late consequences of low dose irradiation is discussed. |
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ISSN: | 0869-8031 |