Protective effect of cortisone against the anti-cellular action of endotoxins

In vitro studies with the phase contrast microscope. The protective effect of sodium 6-methyl-prednisolone hemisuccinate against the effects of a purified Salmonella abortus equi lipopolysaccharide were investigated in the rabbit. The intravenous injection of 8 mg of the cortisone derivative simulta...

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Bibliographic Details
Published inArchivio per le scienze mediche Vol. 126; no. 5; p. 217
Main Authors Magliulo, E, Pilla, G, Quaglia, P, Fossati, G C
Format Journal Article
LanguageItalian
Published Italy 01.05.1969
Subjects
Animals
Anti-Inflammatory Agents - therapeutic use
Cortisone - therapeutic use
Fever - etiology
Fever - prevention & control
Leukocytes - drug effects
Leukocytes - physiology
Leukopenia - etiology
Leukopenia - prevention & control
Lipopolysaccharides - antagonists & inhibitors
Male
Methylprednisolone Hemisuccinate - therapeutic use
Rabbits
Time Factors
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Summary:In vitro studies with the phase contrast microscope. The protective effect of sodium 6-methyl-prednisolone hemisuccinate against the effects of a purified Salmonella abortus equi lipopolysaccharide were investigated in the rabbit. The intravenous injection of 8 mg of the cortisone derivative simultaneously with the injection of the endotoxin considerably attenuated the febbrile and leukopenic action of the latter. The rate of locomotion of the leukocytes in the peripheral blood in animals treated with endotoxin or with endotoxin plus cortisone was also investigated. In animals protected by sodium 6-methyl-prednisolone hemisuccinate the endotoxin caused a smaller decrease of speed of migration of the leukocytes than that observed in animals treated with the lipopolysaccharide alone. These findings are discussed in the light of present knowledge of the mechanism of the anti-cellular action of endotoxins and of the protective action of cortisone.
ISSN:0004-0312