Ultrastructure of mitochondria apparatus of cardiomyocytes in apoptosis induced by long-term anoxia in rats

Apoptosis in cardiomyocytes was induced by incubation of pieces of cardiac tissues under condition of anoxia. Electronmicroscopic investigation detected previously unknown changes in mitochondrial ultrastructure. The mitochondrial population was characterized by morphological heterogeneity. In addit...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 45; no. 11; p. 1073
Main Authors Saprunova, V B, Bakeeva, L E, Iaguzhinskiĭ, L S
Format Journal Article
LanguageRussian
Published Russia (Federation) 2003
Subjects
Animals
Apoptosis
Cell Hypoxia
In Vitro Techniques
Microscopy, Electron
Mitochondria, Heart - metabolism
Mitochondria, Heart - ultrastructure
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - ultrastructure
Rats
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Summary:Apoptosis in cardiomyocytes was induced by incubation of pieces of cardiac tissues under condition of anoxia. Electronmicroscopic investigation detected previously unknown changes in mitochondrial ultrastructure. The mitochondrial population was characterized by morphological heterogeneity. In addition to a mitochondrial population characterized with irrigated cleared matrix, anoxia induced the appearance of an atypical and previously unknown population of small electron-dense cardiomyocyte mitochondria. They were characterized by unusual localization inside electron-light mitochondria ("mitochondria inside mitochondria"). The most part of mitochondria with the irrigated matrix are commonly characterized by unusual types of rearrangements of the inner mitochondrial membrane. Under anoxic conditions, the inner mitochondrial membrane formed electron-dense ordered structures. This is a spongy structure with cells of equal size. Results of our study are discussed in terms of conception of changes in mitochondrial reticulum ultrastructure during apoptosis.
ISSN:0041-3771