Structural and functional changes in various cells following radiation exposure

Structural and functional changes in thymocytes, splenocytes and hepatocytes, taking place under gamma-irradiation of cellular suspensions were investigated. It was found that splenocytes begin to lose their functional activity and structural features at a dose of 2 Gy. Increasing the irradiation do...

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Published inBiofizika Vol. 46; no. 6; p. 1103
Main Authors Paranich, A V, Tyslenko, K V, Frolova, N A, Grigorovich, A V, Doroshenko, A O, Roshal', A D, Aldabaev, Iu V, Zakrevskiĭ, D I, Svetlakova, N N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2001
Subjects
Animals
Dose-Response Relationship, Radiation
Gamma Rays
Hepatocytes - metabolism
Hepatocytes - radiation effects
In Vitro Techniques
Lipid Peroxidation
Malondialdehyde - metabolism
Organ Specificity
Rats
Spleen - cytology
Spleen - metabolism
Spleen - radiation effects
Thymus Gland - cytology
Thymus Gland - metabolism
Thymus Gland - radiation effects
Tocopherols - metabolism
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Summary:Structural and functional changes in thymocytes, splenocytes and hepatocytes, taking place under gamma-irradiation of cellular suspensions were investigated. It was found that splenocytes begin to lose their functional activity and structural features at a dose of 2 Gy. Increasing the irradiation dose leads to the acceleration of these processes. Thymocytes lose rapidly their functional activity at 2 Gy, but they maintain their structure and membrane parameters even after irradiation with a dose of 10 Gy. In comparison with other cell types, hepatocytes exhibit the greatest stability under the influence of gamma-radiation.
ISSN:0006-3029