Contribution of immunohistochemistry and electron microscopy for the diagnosis of meningeal hemangiopericytomas. 15 case reports

Meningeal hemangiopericytomas (HPC) are rare CNS tumors with a pour prognosis compared to meningiomas. In order to define diagnosis criteria, we performed an immunohistochemical and ultrastructural study in respectively 15 and 5 meningeal HPC. The following antibodies anti-KL1, EMA, vimentin, CD34,...

Full description

Saved in:
Bibliographic Details
Published inAnnales de pathologie Vol. 20; no. 5; p. 492
Main Authors Bouvier-Labit, C, Liprandi, A, Piercecchi, M D, Hosseini, H, Hénin, D, Figarella-Branger, D
Format Journal Article
LanguageFrench
Published France 01.10.2000
Subjects
Adult
Aged
Biomarkers - analysis
Brain - pathology
Brain - ultrastructure
Desmosomes - pathology
Desmosomes - ultrastructure
Diagnosis, Differential
Female
Hemangiopericytoma - pathology
Hemangiopericytoma - ultrastructure
Humans
Immunohistochemistry
Male
Meningeal Neoplasms - pathology
Meningeal Neoplasms - ultrastructure
Meningioma - pathology
Meningioma - ultrastructure
Microscopy, Electron
Middle Aged
Online AccessGet more information

Cover

More Information
Summary:Meningeal hemangiopericytomas (HPC) are rare CNS tumors with a pour prognosis compared to meningiomas. In order to define diagnosis criteria, we performed an immunohistochemical and ultrastructural study in respectively 15 and 5 meningeal HPC. The following antibodies anti-KL1, EMA, vimentin, CD34, factor VIII, alpha-smooth actin, estrogen and progesteron receptors (RE, RP) were used in paraffin embedded sections whereas anti-NCAM and E-cadherin antibodies were used on frozen sections when available. We can differentiate meningeal HPC from meningioma because of a complete lack of immunostaining with epithelial markers as well as with NCAM antibody or RE and RP receptors. Besides a positivity with CD34 and alpha-smooth actin antibodies was always observed even focally in HPC. On the other hand, solitary fibrous tumor showed a strong and diffuse positivity with anti CD34 and anti-vimentin antibodies. Electron microscopy can be helpful in some instances showing membrane basal-like substance and absence of desmosomes.
ISSN:0242-6498