The theory and practice of constructing calibration curves in biodozimetry

The methodical peculiarities of experimental construction of regression "dose-effect" relationships used for the dose reconstruction are discussed. The method of computer simulations is applied to study the efficiency of different statistical procedures for plotting regression curves as we...

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Published inRadiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 46; no. 4; p. 447
Main Authors Rubanovich, A V, Snegireva, G P, Shevchenko, Akaeva, E A, Elisova, T V, Kuznetsova, G I, Nilova, I N, Iofa, E L
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2006
Subjects
Calibration
Computer Simulation
Dose-Response Relationship, Radiation
Gamma Rays
Humans
Lymphocytes - radiation effects
Radiometry - methods
Radiometry - standards
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Summary:The methodical peculiarities of experimental construction of regression "dose-effect" relationships used for the dose reconstruction are discussed. The method of computer simulations is applied to study the efficiency of different statistical procedures for plotting regression curves as well as the dependence of errors in dose prediction on the volume of examined material and on the choice of doses for a calibration curve. The causes of essential variability of calibrations obtained by different teams of researchers are discussed. A number of methodical recommendations is given for statistical processing of cytogenetic data. The procedure of constructing calibration dose dependence of the frequency of dicentrics on the basis experiments with in vitro gamma-irradiation of lymphocytes from blood samples of 5 donors is considered in detail. The expressions for statistical errors occurring in the dose reconstruction made on the base of the frequency of aberrations were derived and checked by the computer experiment.
ISSN:0869-8031