The hemodynamic effects of lomir and adalat in patients with postoperative arterial hypertension

• Published in: Anesteziologiia i reanimatologiia no. 5; p. 63
• Main Authors: Eremenko, A A, Ziuliaeva, T P, Bozh'eva, L V, Borisov, R Iu
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.1999
• Subjects: Adult; Aged; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - adverse effects; Calcium Channel Blockers - administration & dosage; Calcium Channel Blockers - adverse effects; Coronary Artery Bypass; Hemodynamics - drug effects; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Isradipine - administration & dosage; Isradipine - adverse effects; Middle Aged; Nifedipine - administration & dosage; Nifedipine - adverse effects; Postoperative Complications - drug therapy; Postoperative Complications - physiopathology; Time Factors
• ISSN: 0201-7563

Comparison of the hypotensive effects of lomir (isradipine) and adalat (nifedipine) in 36 patients showed lomir to be more effective after aortocoronary bypass surgery. Normalization of arterial pressure started 5-10 min after lomir infusion, followed by a 24.5% increase in cardiac output and decrease in peripheral vascular resistance by 43.8%. Arterial pressure did not rise after lomir infusion was discontinued. With adalat, arterial pressure normalized 30 min later, and the therapeutic effect was achieved with a very high dose (5-7 times higher than recommended). Cardiac output did not change, and cardiac arrhythmias were observed in 11.7% patients. Therefore, lomir is a preferable Ca channel blocker for treating postoperative arterial hypertension after aortocoronary bypass surgery.