Surgical sepsis. Part I. Immunologic markers of systemic inflammatory reaction

The aim of the work was to develop accessible methods of laboratory diagnosis of the systemic inflammatory reaction, based on an assessment of biological (inflammatory and immunosuppressive) activity of serum of surgical sepsis patients (n = 104). The investigation has shown that surgical sepsis pat...

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Published inVestnik hirurgii im. I.I. Grekova Vol. 161; no. 3; p. 101
Main Authors Ostanin, A A, Leplina, O Iu, Tikhonova, M A, Zaĭnutdinov, Iu G, Strel'tsova, E I, Ovechkin, A V, Chërnykh, E R
Format Journal Article
LanguageRussian
Published Russia (Federation) 2002
Subjects
Adult
Biomarkers - blood
Female
HLA-DR Antigens - blood
Humans
Inflammation - diagnosis
Inflammation - immunology
Inflammation Mediators - blood
Interleukin-6 - blood
Male
Middle Aged
Sepsis - diagnosis
Sepsis - etiology
Sepsis - immunology
Surgical Procedures, Operative - adverse effects
Tumor Necrosis Factor-alpha - metabolism
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Summary:The aim of the work was to develop accessible methods of laboratory diagnosis of the systemic inflammatory reaction, based on an assessment of biological (inflammatory and immunosuppressive) activity of serum of surgical sepsis patients (n = 104). The investigation has shown that surgical sepsis patients are characterized by marked immune dysfunctions, immunosuppressive bioactivity of blood serum being detected in most patients (in 65.6%) beginning from the earliest stages of the development of the sepsis process. It was found that in patients with dominating suppressive activity of serum the immune disturbances were more pronounced and in every second case they were of combined type. The authors propose to use the degree of the immunosuppressive potential of serum factors as the key classification sign determining the presence of CARS-positive or CARS-negative phenotype in such patients. The results obtained suggest that it is expedient for complex therapy of surgical sepsis to include immunocorrection aimed at the weakening of immunosuppresive action of antiinflammatory mediators and shift of the balance towards the reinforcement of activity of proinflammatory ones (IL-12, IL-1) and Th-1 cytokines (IL-2, IFN-g).
ISSN:0042-4625