Poorly differentiated breast carcinoma with an abundant myoepithelial component: morphologic and immunohistochemical features and mammaglobin gene expression

In this report, we describe a case of poorly differentiate myoepithelial cell rich carcinoma in with morphological findings of large poligonal nests with festoon-like pattern sometimes showing central necrosis, reminiscent of a comedo-like pattern and numerous mitoses. Immunohistochemical staining s...

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Published inPathologica Vol. 95; no. 4; p. 209
Main Authors Bonadio, A G, Ferro, P, Moroni, M, Gorji, N, Giannico, A, Dessanti, P, Fais, F, Bacigalupo, B, Roncella, S, Fedeli, F
Format Journal Article
LanguageItalian
Published Italy 01.08.2003
Subjects
Aged
Biomarkers, Tumor - analysis
Breast Neoplasms - chemistry
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinoma - chemistry
Carcinoma - genetics
Carcinoma - pathology
Epithelial Cells - chemistry
Female
Humans
Mammaglobin A
Myoepithelioma - chemistry
Myoepithelioma - genetics
Myoepithelioma - pathology
Neoplasm Proteins - analysis
Neoplasm Proteins - genetics
Organ Specificity
RNA, Messenger - analysis
RNA, Neoplasm - analysis
Uteroglobin - genetics
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Summary:In this report, we describe a case of poorly differentiate myoepithelial cell rich carcinoma in with morphological findings of large poligonal nests with festoon-like pattern sometimes showing central necrosis, reminiscent of a comedo-like pattern and numerous mitoses. Immunohistochemical staining shows positive reaction for cytokeratin AE/1, CAM 5.2, 34 beta E12, vimentin, smooth muscle actin, EMA, S100 protein and oncogene cERB.b2 and negative for estrogen, progesterone, GFAP and chromogranin. Moreover, this carcinoma show the expression of the mammaglobin mRNA, a highly specific marker of breast epithelial cells that it is not expressed in all breast carcinoma.
ISSN:0031-2983
1591-951X