The peculiarities of renal lesion in nodular polyarteritis

Analysis of the medical records of 122 patients with nodular polyarteritis showed that the most frequent visceral manifestations were renal (93.4%), cardial (72%), and gastrointestinal (57.4%) ones. Central nervous system (CNS), pulmonary, and peripheral arterial lesions were less frequent (36.8%, 1...

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Published inKlinicheskaia meditsina Vol. 84; no. 2; p. 44
Main Authors Klimenko, O V, Semenkova, E N, Krivosheev, O G
Format Journal Article
LanguageRussian
Published Russia (Federation) 2006
Subjects
Acute Kidney Injury - etiology
Adult
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Central Nervous System Diseases - etiology
Gastrointestinal Diseases - etiology
Humans
Hypertension, Renal - etiology
Kidney Diseases - etiology
Kidney Failure, Chronic - etiology
Lung Diseases - diagnostic imaging
Lung Diseases - etiology
Male
Nephrotic Syndrome - etiology
Polyarteritis Nodosa - complications
Polyarteritis Nodosa - mortality
Polyarteritis Nodosa - therapy
Prognosis
Radiography, Thoracic
Risk
Sex Factors
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Summary:Analysis of the medical records of 122 patients with nodular polyarteritis showed that the most frequent visceral manifestations were renal (93.4%), cardial (72%), and gastrointestinal (57.4%) ones. Central nervous system (CNS), pulmonary, and peripheral arterial lesions were less frequent (36.8%, 17.2%, and 6.6%, respectively). Renal lesions were manifested by arterial hypertension (AH) in 107 patients, urinary syndrome in 97, nephrotic syndrome in 7, and rapidly progressing glomerulonephritis in 5 patients. Monofactor analysis revealed the following predictors of poor prognosis: malignant AH, nephrotic proteinuria, male sex, body mass reduction, intestinal ulcers, gastrointestinal hemorrhage, CNS lesion, heart failure, and pulmonary lesion. The relative risk of lethal outcome was the highest in nephrotic proteinuria (3.5) and malignant AH (2.9). In 56% of cases death was caused by cardiovascular complications, in 18%--chronic renal failure, in 11%--abdominal complications.
ISSN:0023-2149