Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais

We recently reported association of a newly identified polymorphism of Fcgamma receptor (FcgammaR) IIb, I232T, with systemic lupus erythematosus (SLE) in Japanese. To date, information on FcgammaR genotypes and their association with SLE is limited in South-east Asian populations. To gain further in...

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Published inTissue antigens Vol. 61; no. 5; pp. 374 - 383
Main Authors Siriboonrit, U, Tsuchiya, N, Sirikong, M, Kyogoku, C, Bejrachandra, S, Suthipinittharm, P, Luangtrakool, K, Srinak, D, Thongpradit, R, Fujiwara, K, Chandanayingyong, D, Tokunaga, K
Format Journal Article
LanguageEnglish
Published England 01.05.2003
Subjects
Adolescent
Adult
Aged
Antigens, CD - genetics
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
GPI-Linked Proteins
Humans
Japan
Linkage Disequilibrium
Lupus Erythematosus, Systemic - epidemiology
Lupus Erythematosus, Systemic - genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, IgG - genetics
Thailand - epidemiology
Thailand
Japan
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Summary:We recently reported association of a newly identified polymorphism of Fcgamma receptor (FcgammaR) IIb, I232T, with systemic lupus erythematosus (SLE) in Japanese. To date, information on FcgammaR genotypes and their association with SLE is limited in South-east Asian populations. To gain further insight into the role of FcgammaR polymorphisms in the genetic predisposition of SLE, association of FcgammaRIIa-H131R, IIb-I232T, IIIa-F176V and IIIb-NA1/NA2 (HNA-1a/1b) polymorphisms with SLE was analyzed in the Thai population, using case-control association analysis. FcgammaRIIb-232T/T and IIIb-NA2/NA2 genotypes were associated with SLE with the odds ratio of 2.55. Genotype relative risk analysis revealed significant association of IIb-232T/T and IIIb-NA2/NA2, and a tendency of association of the IIIa-176F/F genotype. Moreover, carriers of FcgammaRIIa-131R were significantly increased in patients with lupus nephritis. Significant linkage disequilibrium was present among FcgammaRIIb, IIIa and IIIb, and two-locus analyses suggested that the tendency of association of FcgammaRIIIa could derive from linkage disequilibrium with IIb and IIIb. These results provided evidence that FcgammaR polymorphisms may be an important predisposing factor also in Thais in a complex manner.
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ISSN:0001-2815