A new class of functionalized polyoxometalates: synthesis, structure and preliminary antitumor activity studies of three arylimido substituted hexamolybdates bearing a strong electron-withdrawing nitro group, (Bu4N)2[Mo6O18([triple bond]NAr)] (Ar = 3-NO2-C6H4, 2-CH3-4-NO2-C6H3, 2-CH3-5-NO2-C6H3)

• Published in: Dalton transactions : an international journal of inorganic chemistry no. 35; p. 4770
• Main Authors: Xue, Sijia, Chai, An, Cai, Zhijuan, Wei, Yongge, Xiang, Changsheng, Bian, Wangdong, Shen, Jian
• Format: Journal Article
• Language: English
• Published: England 21.09.2008
• Subjects: Aniline Compounds - chemistry; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cell Proliferation - drug effects; Dicyclohexylcarbodiimide - chemistry; Drug Design; Electrons; Humans; Imides - chemistry; K562 Cells; Models, Molecular; Molecular Conformation; Molybdenum - chemistry; Nitro Compounds - chemistry; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Polymers - chemistry; Spectrum Analysis; Tungsten Compounds - chemistry; Water - chemistry
• ISSN: 1477-9234
• DOI: 10.1039/b719388b

Three novel mono-functionalized arylimido derivatives of hexamolybdate bearing the strongest electron-withdrawing nitro group, (Bu(4)N)(2)[Mo(6)O(18)([triple bond]NAr)] (1, 2 and 3), have been synthesized for the first time by an improved reaction of octamolybdate ion and 3-nitroaniline hydrochloride, 2-methyl-4-nitroaniline hydrochloride and 2-methyl-5-nitroaniline hydrochloride respectively with DCC (N,N'-dicyclohexylcarbodiimide) as a dehydrating agent. Complete assignments were achieved for the title compounds by elemental analysis, IR, (1)H NMR, UV/visible and single-crystal X-ray diffraction analyses. The preliminary antitumor activity test indicated that the title compounds have some effects on the cellular growth inhibition of K562 cells.