Comparative characteristics of vanadium-containing compounds, possessing insulin-like effects

The serum glucose concentration, HbAc1, fructoseamine, the activity of AST, ALT, amylase, glycogen content and glucokinase activity in rat hepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadate and vanadyl sulphate treatment. The improvement of this parameters were...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 46; no. 2; p. 155
Main Authors Golubev, M A, Gorodetskiĭ, V K, Anis'kina, A P, Tochilkin, A I, Beliaeva, N F
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2000
Subjects
Animals
Diabetes Mellitus, Experimental - drug therapy
Insulin - pharmacology
Insulin - therapeutic use
Insulin - toxicity
Lethal Dose 50
Liver - drug effects
Male
Molecular Mimicry
Rats
Rats, Wistar
Streptozocin
Vanadium Compounds - pharmacology
Vanadium Compounds - therapeutic use
Vanadium Compounds - toxicity
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Summary:The serum glucose concentration, HbAc1, fructoseamine, the activity of AST, ALT, amylase, glycogen content and glucokinase activity in rat hepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadate and vanadyl sulphate treatment. The improvement of this parameters were demonstrated after oral orthovanadate and vanadyl sulphate administration. However, insulin-mimetic properties of vanadyl sulphate were more marked in comparison with orthovanadate. LD-50 and cytotoxicity analysis in isolated hepatocytes showed that vanadyl sulphate was less toxic than orthovanadate.
ISSN:0042-8809