C-reactive protein value related to a smoking history and composition of nicotine and tobacco tar

The CRP is known to be an acute phase reactant, but with new high sensitivity assay methods it appears that CRP is also a marker of chronic inflammation. This study was to investigate whether smoking acts as a systemic disease and to see if there is a relation between CRP values and smoking. 762 per...

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Published inAnales de medicina interna (Madrid, Spain : 1984) Vol. 23; no. 1; pp. 3 - 10
Main Authors Martín de Diego, C E, Gómez de Terreros Sánchez, F J, Caro de Miguel, M C, Medina Font, J, Matesanz Ruiz, C, Gómez de Terreros Caro, J
Format Journal Article
LanguageSpanish
Published Spain 01.01.2006
Subjects
Adult
C-Reactive Protein - analysis
Chronic Disease
Humans
Inflammation - blood
Inflammation - etiology
Middle Aged
Nicotiana - chemistry
Nicotine - analysis
Smoking - adverse effects
Smoking - physiopathology
Tars - analysis
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Summary:The CRP is known to be an acute phase reactant, but with new high sensitivity assay methods it appears that CRP is also a marker of chronic inflammation. This study was to investigate whether smoking acts as a systemic disease and to see if there is a relation between CRP values and smoking. 762 persons were studied, with a mean age of 41.74+/-10.03 years. 200 were smokers, 344 were non-smokers and 218 were ex-smokers. The following details were noted in the smoking history: cigarette brand, number of cigarettes/day, number of years smoking and milligrams of nicotine and tar. In the case of ex-smokers, the number of years since giving up smoking was noted. The CRP was determined using the high sensitive Tina-Quant assay. Windows SPSS version 11.0 software was used. The CRP values showed statistically significant differences between the smoking and non-smoking groups. A statistically significant increase in CRP was observed in relation to number of cigarettes/day (p=0.001), mg of nicotine (p=0.017), mg of tar (p=0.020) and number of years of smoking (p=0.0001). However, when analysing the relation between CRP and the number of years since giving up smoking, there was a negative curve of 0.02 in the equation, but this was not of statistical significance. CRP levels rise when there is an increase in number of cigarettes/day, mg of nicotine and tar and years smoking.
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ISSN:0212-7199