The study of the human complement cascade of proteolysis as a target of laser irradiation

Samples of human blood plasma were irradiated with the laser beam (lamda=633 nm, P=13 mW, t=20 min) in vitro. In experimental and control (incubated in the dark) samples the complement hemolytic activity was measured. Laser irradiation had minor influence on the duration of lag-period and the rate o...

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Published inBiomeditsinskaia khimiia Vol. 55; no. 1; p. 68
Main Authors Galebskaia, L V, Andreeva, L A, Solovtsova, I L, Solov'eva, M A, Petrishchev, N N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2009
Subjects
Complement System Proteins - chemistry
Hemolysis - radiation effects
Humans
Lasers
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Summary:Samples of human blood plasma were irradiated with the laser beam (lamda=633 nm, P=13 mW, t=20 min) in vitro. In experimental and control (incubated in the dark) samples the complement hemolytic activity was measured. Laser irradiation had minor influence on the duration of lag-period and the rate of complement-dependent hemolysis via classical and alternative pathways; it also did not alter the functional activity of factor B, components C2 and C3. Nevertheless laser irradiation effect was seen in essential reduction of a bystander lysis coefficient. This new fact can elucidate some aspects of the clinical effectiveness of the blood laser irradiation.
ISSN:2310-6972