Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study

Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-de...

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Bibliographic Details
Published inPsychiatry research Vol. 155; no. 3; pp. 265 - 269
Main Authors Kemp, Andrew H, Felmingham, Kim, Das, Pritha, Hughes, Gerard, Peduto, Anthony S, Bryant, Richard A, Williams, Leanne M
Format Journal Article
LanguageEnglish
Published Ireland 15.08.2007
Subjects
Adult
Amygdala - physiopathology
Comorbidity
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - physiopathology
Facial Expression
Fear
Female
Humans
Magnetic Resonance Imaging
Male
Nerve Net - physiopathology
Prefrontal Cortex - physiopathology
Severity of Illness Index
Stress Disorders, Post-Traumatic - epidemiology
Stress Disorders, Post-Traumatic - physiopathology
Surveys and Questionnaires
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Summary:Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0165-1781