Anti-Sp100 and anti-Gp210 in the diagnosis of primary biliary cirrhosis in patients with autoimmune cholangitis

We describe 2 women with features of autoimmune cholangitis. Serum biochemical studies showed cholestasis and increased immunoglobulin M with negative antimitochondrial antibodies. Markers of hepatitis B and C viruses were absent. Both had positive antinuclear antibodies. One had a speckled pattern...

Full description

Saved in:
Bibliographic Details
Published inGastroenterología y hepatología Vol. 22; no. 1; p. 11
Main Authors Romero Gómez, M, Wichmann, I, Otero Fernández, M A, Suárez García, E, Grande, L, Núñez, J, Nevado Santos, M, Castro Fernández, M
Format Journal Article
LanguageSpanish
Published Spain 01.01.1999
Subjects
Antibodies, Antinuclear - blood
Antigens, Nuclear
Autoantigens - immunology
Autoimmune Diseases - diagnosis
Cholangitis - diagnosis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoblotting
Liver Cirrhosis, Biliary - diagnosis
Membrane Glycoproteins - immunology
Middle Aged
Mitochondria - immunology
Molecular Weight
Nuclear Pore Complex Proteins
Nuclear Proteins - immunology
Online AccessGet more information

Cover

More Information
Summary:We describe 2 women with features of autoimmune cholangitis. Serum biochemical studies showed cholestasis and increased immunoglobulin M with negative antimitochondrial antibodies. Markers of hepatitis B and C viruses were absent. Both had positive antinuclear antibodies. One had a speckled pattern (multiple nuclear dots) and the other a perinuclear pattern (pore nuclear). In the first case anti-Sp100 was positive by EIA and in the second anti-Gp210 was detected by immunoblot. Diagnosis of primary biliary cirrhosis was made and the patients were treated with UDCA. Current knowledge indicates that determination of anti-Sp100 and anti-Gp210 substantially improves diagnosis of primary biliary cirrhosis as these ANA are highly specific for this disease. These autoantibodies may lead to the classification of different groups of patient included in autoimmune cholangitis. All patients with autoimmune cholangitis should be tested for anti-Sp100 and anti-Gp210.
ISSN:0210-5705