LTR retrotransposons from genomes of Aspergillus fumigatus and A. nidulans

Fungi Aspergillus spp. are able to infect all tissues and organs and often cause invasive mycosis (aspergillosis), which is usually a fatal disease, especially in the patients with compromised immune system. Microbiological monitoring of these infectious agents is necessary in modem medical faciliti...

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Bibliographic Details
Published inMolekuliarnaia biologiia Vol. 41; no. 5; p. 830
Main Authors Novikova, O S, Fet, V, Blinov, A G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2007
Subjects
Aspergillosis - genetics
Aspergillosis - immunology
Aspergillus fumigatus - genetics
Aspergillus fumigatus - immunology
Aspergillus nidulans - genetics
Aspergillus nidulans - immunology
Genome, Fungal - genetics
Genome, Fungal - immunology
Open Reading Frames - genetics
Open Reading Frames - immunology
Phylogeny
Retroelements - genetics
Retroelements - immunology
Sequence Analysis, DNA - methods
Species Specificity
Terminal Repeat Sequences - genetics
Terminal Repeat Sequences - immunology
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Summary:Fungi Aspergillus spp. are able to infect all tissues and organs and often cause invasive mycosis (aspergillosis), which is usually a fatal disease, especially in the patients with compromised immune system. Microbiological monitoring of these infectious agents is necessary in modem medical facilities. Mobile elements can be used as markers for identification of species and strains of Aspergillus found indoors as well as in aspergillosis diagnostics. Genomic sequences of two representative Aspergillus species, A. fumigatus and A. nidulans, were analysed in silico in order to detect LTR retrotransposons. We found considerable differences in the composition of retrotransposon families between two studied species. One of the detected families, which is present in both studied Aspergillus species, is phylogenetically quite different from all other known fungal retrotransposons. The majority of elements are represented by damaged copies. Nevertheless, we describe for the first time allegedly non-damaged LTR copies that contain intact ORFs and could be active.
ISSN:0026-8984