Phenotype of peripheral blood lymphocytes in patients with lung cancer

The expression of surface markers of blood lymphocytes was studied in 32 lung cancer patients. Tumor process involved enhanced expression of the activation markers CD25, CD71 and HLA-DR as well as differentiation antigens CD4, CD8, CD22 and CD16. The expression of the markers was higher than in cont...

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Bibliographic Details
Published inVoprosy onkologij Vol. 47; no. 4; p. 436
Main Authors Oleĭnik, E K, Oleĭnik, V M, Bakhlaev, I E, Ageenko, A I
Format Journal Article
LanguageRussian
Published Russia (Federation) 2001
Subjects
B-Lymphocytes - immunology
Case-Control Studies
Humans
Immunophenotyping
Lung Neoplasms - blood
Lung Neoplasms - immunology
Phenotype
T-Lymphocytes - immunology
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Summary:The expression of surface markers of blood lymphocytes was studied in 32 lung cancer patients. Tumor process involved enhanced expression of the activation markers CD25, CD71 and HLA-DR as well as differentiation antigens CD4, CD8, CD22 and CD16. The expression of the markers was higher than in control, irrespective of stage, localization and histological pattern of tumor. It is suggested that increased expression of surface markers should be accounted for by tumor-induced suppression of the immune system in lung cancer.
ISSN:0507-3758