The serum gastrin level in patients with schistosomiasis and fascioliasis

The study assessed changes in fasting serum gastrin level in early schistosomiasis and chronic fascioliasis in 52 patients. Forty patients had either schistosomiasis or fascioliasis alone. Twelve patients had combined infection with both parasitosis. Also, ten healthy parasite free individuals were...

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Bibliographic Details
Published inJournal of the Egyptian Society of Parasitology Vol. 37; no. 1; p. 299
Main Authors Abou Holw, Sahar A, El-Taweel, Hend A, Elabd, Eman A, Osman, Mervat M
Format Journal Article
LanguageEnglish
Published Egypt 01.04.2007
Subjects
Alkaline Phosphatase - blood
Alkaline Phosphatase - metabolism
Analysis of Variance
Animals
Case-Control Studies
Fascioliasis - blood
Fascioliasis - parasitology
Feces - parasitology
Female
Gastrins - blood
Humans
Liver Function Tests
Male
Parasite Egg Count
Radioimmunoassay - methods
Schistosomiasis - blood
Schistosomiasis - parasitology
Severity of Illness Index
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Summary:The study assessed changes in fasting serum gastrin level in early schistosomiasis and chronic fascioliasis in 52 patients. Forty patients had either schistosomiasis or fascioliasis alone. Twelve patients had combined infection with both parasitosis. Also, ten healthy parasite free individuals were selected as a control. All were clinically examined and subjected to stool analysis, liver function tests and sero-diagnosis for H. pylori. Serum gastrin was measured by radioimmunoassay and showed significant elevation in all patients (with schistosomiasis, fascioliasis or both parasites) compared to controls. A significantly higher serum gastrin level was detected among patients with combined infection relative to either with schistosomiasis or fascioliasis. Alkaline phosphatase activity increased significantly in all patients as compared to control. The activity of the enzyme had significant positive correlation with egg counts in patients with either parasite and with serum gastrin level in those with combined infection. The results were discussed.
ISSN:1110-0583