Uncoupling protein 3 and peroxisome proliferator-activated receptor gamma2 contribute to obesity and diabetes in palauans

• Published in: Biochemical and biophysical research communications Vol. 281; no. 3; pp. 772 - 778
• Main Authors: Yanagisawa, Y, Hasegawa, K, Dever, G J, Otto, C T, Sakuma, M, Shibata, S, Miyagi, S, Kaneko, Y, Kagawa, Y
• Format: Journal Article
• Language: English
• Published: United States 02.03.2001
• Subjects: Adipose Tissue; Asian Continental Ancestry Group; Base Sequence; Body Composition; Carrier Proteins - physiology; DNA Primers; Female; Genotype; Humans; Ion Channels; Male; Middle Aged; Mitochondrial Proteins; Obesity - ethnology; Obesity - physiopathology; Receptors, Cytoplasmic and Nuclear - physiology; Transcription Factors - physiology; Uncoupling Protein 3
• ISSN: 0006-291X

We examined the genetic contribution of single nucleotide polymorphisms (SNPs) of the energy metabolism-related genes, including beta 3 adrenergic receptor (beta3AR), apolipoprotein E (apo-E), promoter of uncoupling protein 3 (UCP3-p), peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) and leptin receptor (LEPR) to metabolic disorders, in 118 inhabitants of Palau. The data were statistically analyzed and ethnically compared to correlate SNPs and their metabolic parameters. UCP3-p (P < 0.01) and PPARgamma2 (p = 0.05) correlated with plasma HbA1c, and UCP3-p correlated with fasting blood glucose (P < 0.01) in males, but not in females. UCP3-p correlated with body fat (%) (P < 0.01) in females, but not in males. Plasma leptin levels and apo-E were correlated in both groups. The frequency of SNPs for PPARgamma2, LEPR, and UCP3-p are significantly different between Palauans and Caucasians.