Effects of theraphthal-Lio on hemostasis in experimental animals

Teraphtal-Lio (Tph) exerted a toxic dose-dependent effect on the hemostatic system. Treatment of experimental animals with maximum tolerated and highly toxic doses was followed by acute DVS syndrome formation involving a hemophilic condition, soaring activated partial prothrombin time, absence of fi...

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Published inVoprosy onkologij Vol. 47; no. 6; p. 715
Main Authors Madzhuga, A V, Ermakova, N P, Chlenova, E L, Koniaeva, O N, Somonova, O V, Elizarova, A L, Mikhaĭlova, L M
Format Journal Article
LanguageRussian
Published Russia (Federation) 2001
Subjects
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Antineoplastic Agents - toxicity
Blood Coagulation Disorders - chemically induced
Blood Coagulation Tests
Disseminated Intravascular Coagulation - chemically induced
Hemostasis - drug effects
Humans
Indoles - administration & dosage
Indoles - adverse effects
Indoles - toxicity
Injections, Intravenous
Male
Rats
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Summary:Teraphtal-Lio (Tph) exerted a toxic dose-dependent effect on the hemostatic system. Treatment of experimental animals with maximum tolerated and highly toxic doses was followed by acute DVS syndrome formation involving a hemophilic condition, soaring activated partial prothrombin time, absence of fibrinogen, sharp rise in fibrinogen degradation product and D-dimer matched by fall in thrombocyte count. No toxic influence on the hemostatic system was registered when Tph doses recommended for humans in the course of phase II clinical trials were administered to animals.
ISSN:0507-3758