Lactogenic effects of hyperinsulinemic-euglycaemic clamp in goats

In the experiment performed on lactating goats, insulin was infused into the jugular vein over during 2 days every day at the rate 2 mg/kg/hour during 6 hour synchronously with glucose at variable rate to maintain euglycaemia; the transport activity (T, in clearance units) was estimated using the eq...

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Bibliographic Details
Published inRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 93; no. 4; p. 402
Main Authors Makar, Z N, Cherepanov, G G, Sapunov, M I, Korneeva, R I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.2007
Subjects
Animals
Blood Glucose - analysis
Female
Glucose - administration & dosage
Glucose Clamp Technique
Goats - physiology
Insulin - administration & dosage
Insulin - blood
Lactation - drug effects
Mammary Glands, Animal - blood supply
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - metabolism
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Summary:In the experiment performed on lactating goats, insulin was infused into the jugular vein over during 2 days every day at the rate 2 mg/kg/hour during 6 hour synchronously with glucose at variable rate to maintain euglycaemia; the transport activity (T, in clearance units) was estimated using the equation: T = Q x E/ (1-E), where Q is plasma flow and E is extraction efficiency. At the end of infusion of the 1st and 2nd days, insulin level in the blood was increased by 63 and 82%, mammary plasma flow by 38 and 78%, milk secretion rate by 23.7 and 31.3 %, milk protein yield by 21.4 and 40%, transport activity of glucose by 63 %, and amino acids by 18% (all p < 0.05) compared to control, respectively. The data obtained suggest that productive effect resulted from elevated metabolic activity of secretory cells and increased mammary blood flow.
ISSN:0869-8139